基本解释：质子溶剂
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In the process of cyclisation of the compound, the aprotic solvent was used by place of the protic one, thereby, the reaction time was shortened and the yield was higher than that reported in the literature.对 3-羟基 - 1,5 -二氮杂环庚烷的合成进行了改进 ,在成环反应中以非质子溶剂代替了质子溶剂 ,缩短了反应时间 ,产率较文献有较大提高 。
Using non-protonic solvent,the technology gave high yield (90%) and good quality (93%).本文应用非质子溶剂为介质合成Ｏ，Ｏ－二甲基硫代磷酰氯可较明显的提高质量和收率，降低反应物投料配比。
